Are referendum results binding?

Ghana
THE CONSTITUTION OF THEREPUBLIC OF GHANA (2002)
http://www.judicial.gov.gh/constitution/second_schedule/home.htm
Article5.
(8) The President shall, underclause (1) of this article, and acting in accordance with the results of thereferendum held under clauses (4) and (5) of this article, issue aconstitutional instrument giving effect, or enabling effect to be given, to theresults.