Advancing sustainable, inclusive, science- and evidence-based solutions for the 2030 Agenda for Sustainable Development and its Sustainable Development Goals for leaving no one behind: Report of the Secretary-General.

The world is experiencing an unprecedented series of rapid and unpredictable shifts driven by geopolitical tensions, trade wars, deepening socioeconomic inequalities, accelerating climate change, loss of biodiversity and other challenges undermining sustainable development prospects. These trends are also weakening the will to seek multilateral solutions based on the rule of law. At the same time, scientific discoveries and technological innovation are expanding exponentially, generating opportunities for breakthroughs that can overcome barriers to progress and advance science- and evidence-based solutions for inclusive sustainable development. An effective science-policy interface is a key to driving transformational change by enabling policymakers to advance evidence-based decisions with strategic foresight. The present report provides an analysis of barriers to advancing progress towards the Sustainable Development Goals under review at the high-level political forum on sustainable development in 2025, highlights practical measures for coordinated policy implementation and targeted actions that can advance science- and evidence-based solutions, and provides recommendations on how countries can advance these solutions more effectively, including through multi-stakeholder cooperation.